Mitoxantrone, Catalog: 1885

Alternate Names 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione

Appearance Dark blue solid

CAS # 65271-80-9

Molecular Formula C₂₂H₂₈N₄O₆

Molecular Weight 444.48

Purity ≥ 98%

Solubility DMSO (~88 mg/ml)

SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO

InChi InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2

InChi Key KKZJGLLVHKMTCM-UHFFFAOYSA-N

PubChem CID 4212

MDL Number MFCD00242942

Handling Protect from air and light

Storage Conditions-20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Mitoxantrone is an anti-tumor antibiotic and a type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells.