NIAD-4, Catalog: 2710

Alternate Names 2-[[5-[5-(4-hydroxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile

Appearance Crystalline solid

CAS # 868592-56-7

Molecular Formula C₁₈H₁₀N₂OS₂

Molecular Weight 334.41

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES C1=CC(=CC=C1C2=CC=C(S2)C3=CC=C(S3)C=C(C#N)C#N)O

InChi InChI=1S/C18H10N2OS2/c19-10-12(11-20)9-15-5-6-17(22-15)18-8-7-16(23-18)13-1-3-14(21)4-2-13/h1-9,21H

InChi Key KLFRZDOQQDHVSS-UHFFFAOYSA-N

PubChem CID 9639427

Handling Protect from air and light

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

NIAD-4 is a novel class of fluorescent probe, having good blood-brain barrier permeability, specificity to amyloid-β plaques, and "turn-on" bright far-red emission upon Aβ binding. NIAD-4 has a structure geometry that is readily planarized and results in a red shift upon binding to Aβ. The highly polarizable bridge provides a substantial bathochromic shift in both absorption and emission spectra of the agent.