Mirin, Catalog: B1075

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Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

PRODUCT SUMMARY

Alternate Names Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

Appearance Pale yellow solid

CAS # 1198097-97-0 

Molecular Formula C₁₀H₈N₂O₂S

Molecular Weight 220.25

Purity ≥98% by HPLC

Solubility DMSO (>20 mg/ml)

SMILES C1=CC(=CC=C1C=C2C(=O)N=C(S2)N)O

InChi InChI=1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-

InChi Key YBHQCJILTOVLHD-YVMONPNESA-N

PubChem CID 1206243

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀ = 12 μM) and induces G2 cell cycle arrest.