AKR1C3 Inhibitor II, Catalog: 2404

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1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one

PRODUCT SUMMARY

Alternate Names 1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one

Appearance White to off-white solid

Molecular Formula C₁₆H₂₂N₂O₃S

Molecular Weight 322.42

Purity ≥ 98% by HPLC

Solubility DMSO

SMILES O=C1N(C2=CC=C(S(=O)(N3C(C)CCCC3)=O)C=C2)CCC1

InChi InChI=1S/C16H22N2O3S/c1-13-5-2-3-12-18(13)22(20,21)15-9-7-14(8-10-15)17-11-4-6-16(17)19/h7-10,13H,2-6,11-12H2,1H3

InChi Key KCSTYGPHSVKBQP-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.