Antipain dihydrochloride, Catalog: 2834

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[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl

PRODUCT SUMMARY

Alternate Names [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl

Appearance White to off-white solid

CAS # 37682-72-7

Molecular Formula C₂₇H₄₄N₁₀O₆.2HCl

Molecular Weight 677.62

Purity ≥ 97% by HPLC

Solubility H2O (> 50 mg/ml) or DMSO (5 mg/ml)

SMILES CC(C)C(C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C(CCCN=C(N)N)NC(=O)NC(CC1=CC=CC=C1)C(=O)O.Cl.Cl

InChi InChI=1S/C27H44N10O6.2ClH/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43);2*1H

InChi Key YAHXZYICKJUJEO-UHFFFAOYSA-N

PubChem CID 24847649

MDL Number MFCD00135957

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Antipain is a reversible protease inhibitor that inhibits cathepsin A, B, and D as well as papain, trypsin and trypsin-like serine proteases. Antipain is more specific for papain and trypsin than is leupeptin (Cat. No. 1648). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.