TCS PIM-1 1, Catalog: 2848
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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Alternate Names 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
Appearance Yellow solid
CAS # 491871-58-0
Molecular Formula C₁₈H₁₁BrN₂O₂
Molecular Weight 367.2
Purity ≥ 98% by HPLC
Solubility DMSO (>35 mg/ml)
SMILES C1=CC=C(C=C1)C2=C(C(=O)NC(=C2)C3=C(C=CC(=C3)Br)O)C#N
InChi InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
InChi Key SVSYJTYGPLVUOZ-UHFFFAOYSA-N
PubChem CID 1235170
MDL Number MFCD00276275
Storage Conditions -20°C
Shipping Conditions Gel Pack
Usage For Research Use Only! Not For Use in Humans.
Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.
TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).