NSC-319726, Catalog: 9439
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1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Alternate Names 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
Appearance White solid
CAS # 71555-25-4
Molecular Formula C₁₁H₁₄N₄S
Molecular Weight 234.32
Purity ≥ 98%
Solubility DMSO (>20 mg/ml)
SMILES CC(=NNC(=S)N1CCC1)C2=CC=CC=N2
InChi InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9-
InChi Key XDHBUMNIQRLHGO-LCYFTJDESA-N
PubChem CID 5921672
Storage Conditions -20°C
Shipping Conditions Gel Pack
Usage For Research Use Only! Not For Use in Humans.
Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.
NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.