Dextromethorphan (hydrobromide hydrate), Cell-Permeable, Catalog: 2912

Alternate Names (9α,13α,14α)-3-methoxy-17-methyl-morphinan, hydrobromide monohydrate

Appearance Crystalline solid

CAS # 6700-34-1

Molecular Formula C₁₈H₂₅NO • HBr [H₂O]

Molecular Weight 370.3

Purity ≥ 98%

Solubility PBS, pH 7.2 (5 mg/ml), Ethanol or DMF (20 mg/ml), DMSO (12 mg/ml). Organic solvents should be purged in inert gas. Aqueous solutions should not be stored for >1 day.

SMILES CN1[C@@H]2[C@@]3([H])CCCC[C@@]3(CC1)C4=CC(OC)=CC=C4C2

InChi InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

InChi Key MKXZASYAUGDDCJ-NJAFHUGGSA-N

PubChem CID 5462351

MDL Number MFCD02173901

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.