WHI-P131, Catalog: 1853

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4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

PRODUCT SUMMARY

Alternate Names 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol

Appearance White to off-white solid

CAS # 202475-60-3

Molecular Formula C₁₆H₁₅N₃O₃

Molecular Weight 297.31

Purity ≥ 98% by TLC

Solubility DMSO (~50mg/ml

SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

InChi InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)

InChi Key HOZUXBLMYUPGPZ-UHFFFAOYSA-N

PubChem CID 3794

MDL Number MFCD11045992

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC₅₀ value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.