AZD-3463, Catalog: 2371

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2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl

PRODUCT SUMMARY

Alternate Name 2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl

Appearance Crystalline solid

CAS # 1356962-20-3

Molecular Formula C₂₄H₂₅ClN₆O

Molecular Weight 448.95

Purity ≥ 98% by HPLC

Solubility DMSO (~20 mg/ml)

SMILES COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl

InChi InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)

InChi Key GCYIGMXOIWJGBU-UHFFFAOYSA-N

PubChem CID 56599293

Storage Conditions -20 ̊C 

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

AZD-3463 is a potent ALK (Anaplastic Lymphoma Kinase)/IGFR1 dual inhibitor that displays the ability to overcome acquired resistance to Crizotinib.