Leelamine hydrochloride, Catalog: 2717

Alternate Names 1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, hydrochloride; Dehydroabietylamine

Appearance White solid

CAS # 16496-99-4

Molecular Formula C₂₀H₃₁N.HCl

Molecular Weight 321.93

Purity ≥ 98% by HPLC

Solubility DMSO (~ 30 mg/ml) or EtOH (~30 mg/ml)

SMILES CCCC1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C

InChi InChI=1S/C20H31N/c1-4-6-15-7-9-17-16(13-15)8-10-18-19(2,14-21)11-5-12-20(17,18)3/h7,9,13,18H,4-6,8,10-12,14,21H2,1-3H3/t18?,19-,20+/m0/s1

InChi Key GWCJWLXMNCMNTG-NRRUETGQSA-N

PubChem CID 46780578

Storage Conditions -20°C

Shipping Conditions Gel Pack

Usage For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Leelamine is a diterpene molecule that displays weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM. Leelamine is also an inhibitor of pyruvate dehydrogenase kinase (PDK) (IC₅₀ = 9.5 µM). Recently, Leelamine has been shown to simultaneously inhibit PI3K, MAPK and STAT3 pathways.