Sulfasalazine, Catalog: B2331

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2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid; NSC-667219; NSC-203730

PRODUCT SUMMARY

Alternate Names 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]-benzoic acid; NSC-667219; NSC-203730

Appearance Light yellow to light brown solid

CAS # 599-79-1

Molecular Formula C₁₈H₁₄N₄O₅S 

Molecular Weight 398.39

Purity ≥ 98%

Solubility >25 mg/ml (DMSO)

SMILES C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)NN=C3C=CC(=O)C(=C3)C(=O)O

InChi InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,20H,(H,19,22)(H,24,25)/b21-13-

InChi Key OQANPHBRHBJGNZ-BKUYFWCQSA-N

PubChem CID 5359476

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

DESCRIPTION

Sulfasalazine is an anti-inflammatory agent and GST inhibitor. Sulfasalazine inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells. It also inhibits degradation of IκBα and prevents nuclear translocation of NF-κB induced by TNF-α.