SRPIN340, Catalog: 2458

IN STOCK!
US$0.00

N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; SRPK Inhibitor

PRODUCT SUMMARY

Alternate Names N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; SRPK Inhibitor

Appearance Light yellow solid

CAS # 218156-96-8 

Molecular Formula C₁₈H₁₈F₃N₃O

Molecular Weight 349.35

Purity ≥ 98% by HPLC

Solubility DMSO (~100 mg/ml)

SMILES O=C(C1=CC=NC=C1)NC2=CC(C(F)(F)F)=CC=C2N3CCCCC3

InChi InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)

InChi Key DWFGGOFPIISJIT-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

DESCRIPTION

An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs) significantly, including Clk1 and Clk4 and >140 other SR kinases. SRPIN340 also suppresses VEGF expression and attenuates choroidal neovascularization (CNV).