BMS-303141, Catalog: 2821

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3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide

PRODUCT SUMMARY

Alternate Names 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide

Appearance White solid

CAS # 943962-47-8

Molecular Formula C₁₉H₁₅Cl₂NO₄S

Molecular Weight 424.3

Purity ≥ 98% by HPLC

Solubility DMSO (~10 mg/ml) or EtOH (~ 20 mg/ml)

SMILES COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC(=CC(=C3O)Cl)Cl

InChi InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3

InChi Key SIIPNDKXZOTLEA-UHFFFAOYSA-N

PubChem CID 16747776

Handling Protect from air and light

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

DESCRIPTION

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.