RVX-208, Catalog: 9408

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2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone; Apabetalone

PRODUCT SUMMARY

Alternate Names 2-​[4-​(2-​hydroxyethoxy)-​3,​5-​dimethylphenyl]-​5,​7-​dimethoxy-​4(3H)-​quinazolinone; Apabetalone

Appearance Off-white solid

CAS # 1044870-39-4

Molecular Formula C₂₀H₂₂N₂O₅

Molecular Weight 370.4

Purity ≥ 98% by HPLC

Solubility DMSO (~ 50 mg/ml)

SMILES CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC

InChi InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-

InChi Key NETXMUIMUZJUTB-UHFFFAOYSA-N

PubChem CID 24871506

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air, light and moisture.

DESCRIPTION

RVX-208 is a potent inhibitor of BET bromodomains. It increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.