Iberdomide, Catalog: B2284

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(S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; CC-220

PRODUCT SUMMARY

Alternate Names (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; CC-220

Appearance White to off-white solid

CAS # 1323403-33-3

Molecular Formula C₂₅H₂₇N₃O₅

Molecular Weight 449.5

Purity ≥ 98% by HPLC

Solubility DMSO (>10 mg/ml)

SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3OCC4=CC=C(C=C4)CN5CCOCC5

InChi InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1

InChi Key IXZOHGPZAQLIBH-NRFANRHFSA-N

PubChem CID 67335295

Storage Conditions -20°C

Shipping Conditions Gel Pack

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

DESCRIPTION

Iberdomide is a celebron modulator that displays an IC₅₀ of 60 nM in TR-FRET cereblon binding assay. Cereblon is a substrate receptor in the CRL4 ubiquitin ligase complex. Iberdomide is potentially useful for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease that is characterized by production of autoantibodies.