Sarcosine Assay, Catalog: MA-0207

Catalog MA-0207

Size 100 wells

Sample Type Cell Lysate, Tissue Extracts, Serum, Plasma, Urine, Other Biological Fluids

Method of Detection Colorimetric, OD 570 nm or Fluorometric, Ex/Em = 535/587 nm

Assay Type Quantitative

Application A plate based simple, and sensitive means of quantifying sarcosine levels in a variety of sample types.  

Sensitivity < 1 µM

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Sarcosine, a naturally occurring amino acid, has several metabolic effects with potential health implications. Initially regarded as only an intermediate in glycine metabolism, it appears to be involved in a variety of physiological functions. Sarcosine arises mainly from glycine metabolism, via sarcosine dehydrogenase. Sarcosine serves as a substrate for glycine-N-methyltransferase, contributing to synthesis of dimethylglycine and methionine, members of one-carbon metabolism. Sarcosine has neuromodulatory effects, inhibiting Glycine Transporter 1, increasing synaptic glycine levels and enhancing NMDA receptor function, implicating sarcosine in synaptic neurotransmission and cognition. This suggests a possible utility in treatment of schizophrenia and depression, where NMDA receptor dysfunction is implicated. Elevated sarcosine correlates with aggressive tumor phenotypes and metastasis, particularly in prostate cancer, suggesting its utility also as a biomarker. AkrivisBio’s Sarcosine Assay is a simple, sensitive way of quantifying sarcosine levels in a variety of sample types with a sensitivity below 1 µM.