Givinostat hydrochloride monohydrate , Catalog: B2081

Alternate NameDiethyl-[6-(4-hydroxycarbamoyl-phenyl carbamoyloxymethyl)-naphthalen-2-yl methyl]-ammonium chloride, ITF2357, N-[4-[(Hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride

AppearanceA crystalline solid

CAS # 732302-99-7

Molecular Formula C₂₄H₃₀ClN₃O₅

Molecular Weight475.97

Purity ≥ 98% 

Solubility DMSO: ≥ 100 mg/ml

SMILES CC[N+](CC)([H])CC1=CC=C(C=C(COC(NC2=CC=C(C(NO)=O)C=C2)=O)C=C3)C3=C1.[Cl-].O

InChi 1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2

InChi KeyFKGKZBBDJSKCIS-UHFFFAOYSA-N

Storage Conditions -20°C

Shipping Conditions Room Temperature

USAGE For Research Use Only! Not For Use in Humans.

Handling Do not take it internally. Wear a glove and mask when handling the product. Protect from air and moisture.

Givinostat is an experimental drug and a selective histone deacetylase (HDAC) inhibitor with an IC50 of 198 nM
for HDAC1 and 157 nM for HDAC3.