DPP4 Activity Assay, Catalog: MA-0268

Catalog MA-0268

Size 100 wells

Sample Type Cell & Tissue Extracts, Plasma, Serum, Other Biological Fluids

Method of Detection Fluorometric, Ex/Em = 360/460 nm

Assay Type Quantitative

Application A plate-based simple, sensitive fluorometric assay to measure DPP4 in biological samples.

Sensitivity ~1 µUnit

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Dipeptidyl peptidase-4 (DPP4), also known as CD26, is a multifunctional protein, involved in immune regulation, signal transduction, apoptosis and glucose metabolism and has become a significant target in the treatment of type 2 diabetes mellitus. This enzyme exists in both membrane- bound and soluble forms. DPP4's function as a serine exopeptidase cleaves X-proline or X-alanine dipeptides from the N-terminus of polypeptides. This is particularly important in the regulation of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By rapidly degrading these hormones, DPP4 plays a key role in glucose homeostasis. In the context of type 2 diabetes treatment, DPP4 inhibitors (gliptins) have been developed to prevent the inactivation of GLP-1 and GIP, causing increased insulin secretion, reduced glucagon secretion, and ultimately, lower blood glucose levels. AkrivisBio’s DPP4 Activity Assay is a simple, sensitive way to measure DPP4 in biological samples with a sensitivity of  ~1 µUnit.