α-L-Fucosidase Assay, Catalog: MA-0278

Catalog MA-0278

Size 100 wells

Sample Type Biological Fluids such as Serum, Plasma, Saliva, etc.

Method of Detection Colorimetric, OD 405 nm

Assay Type  Quantitative

Application A plate-based simple, sensitive colorimetric assay to measure α-L-Fucosidase activity in biological samples, including serum.

Sensitivity < 100 µU per well

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

α-L-Fucosidase (AFU) is responsible for cleaving fucose residues from various substrates, including glycolipids, glycoproteins, and oligosaccharides. Alpha-L-fucosidase is involved in various cellular processes, including development, apoptosis, and inflammation. Its activity influences cell surface properties and signaling pathways, affecting cell behavior and fate. AFU is essential for the breakdown of fucosylated glycoconjugates in lysosomes. These compounds are important components of cell membranes and play roles in cell-cell recognition, signaling, and immune response. AFU is a potential biomarker for hepatocellular and colorectal cancer. Serum levels are normally very low but increase significantly during cancer. Fucosylated oligosaccharides appear to be involved in modulating immune responses and maintaining gut health. Serum AFU normal range is ~ 5 - 40 mU/ml. AkrivisBio’s α-L-Fucosidase Assay is a simple sensitive means of measuring AFU activity in biological samples, including serum, with a sensitivity below 100 µU per well.