Glycerol-3-phosphate is an important metabolite that is at the intersection of glucose, lipid, and energy metabolism. Its significance stems from its involvement in multiple metabolic pathways and its role as a regulatory molecule. It participates in glycolysis, gluconeogenesis, glycerolipid synthesis, the electron shuttle system for the electron transport chain, and regulates glucose and lipid metabolism, the cellular redox state, mitochondrial energy production and insulin secretion. The metabolic flexibility provided by G3P and its regulatory enzymes is crucial for cellular adaptation to various nutritional states and metabolic stresses. Alterations in G3P homeostasis have been linked to obesity, insulin resistance, and type 2 diabetes. Furthermore, the newly discovered 'glycerol shunt' pathway, which produces glycerol from G3P, has implications for our understanding of metabolic health, disease, and aging. AkrivisBio’s Glycerol-3-phosphate Assay is a simple, sensitive way to measure G3P in a variety of sample types with a sensitivity below 1 nmole per sample.
