PicoSense Formaldehyde Assay, Catalog: MA-0273

Catalog MA-0273

Size 100 wells

Sample Type Tissue & Cell Lysates, Serum, Plasma, Saliva, Urine

Method of Detection Fluorometric, Ex/Em = 535/587 nm

Assay Type Quantitative

Application A plate-based simple, and highly sensitive fluorometric assay to quantitate Formaldehyde in a variety of samples.

Sensitivity < 50 picomoles

Storage Conditions -20°C

Shipping Temperature Gel Pack

Shelf Life One year from the date of delivery

Formaldehyde (HCHO) serves as an intermediate in one-carbon metabolism. It is rapidly condensed with tetrahydrofolate to enter the 1C cycle, providing essential units for nucleotide biosynthesis, particularly important when serine catabolism is impaired. Formaldehyde's dual nature as both a potential toxin and a valuable metabolic resource is largely maintained by alcohol dehydrogenase 5, which not only detoxifies HCHO but also supports essential metabolism. An alternative pathway involves the reaction of HCHO with cysteine and histidine, forming timonacic and spinacine which can act as a HCHO buffer reservoir. HCHO affects glucose metabolism and impacts cellular energy metabolism. AkrivisBio’s PicoSense Formaldehyde Assay is a simple, highly sensitive way to quantitate HCHO in a variety of samples with a sensitivity  below 50 picomoles.